Preheat oven to 400 F. In a large bowl, combine ground beef with Italian seasoning. Form mixture into 4 equal sized patties and place onto a large greased baking sheet. Bake for 20-25 minutes.
Remove from oven, top with pizza sauce, shredded mozzarella cheese and 2 slices of pepperoni on each burger. Bake for another 5-7 minutes. Serve on hamburger buns.