Preheat oven to 400 F. In a large bowl, combine ground beef, salt, pepper, onion powder, garlic powder and worcestershire sauce. Mix until evenly combined.
Spread the ground beef mixture evenly into a greased baking dish. Bake for 15-20 minutes. Drain the grease from the pan. Top the burger with cheddar cheese slices and bake for another 5-10 minutes, until the cheese is fully melted. Slice burger into sqaures and serve on mini slider buns.