Preheat oven to 350 F. In a large bowl, combine ground beef with breadcrumbs, salt, pepper, onion powder, garlic powder, ketchup, mustard, milk, egg, cooked and crumbled bacon and shredded cheddar cheese.
Form the meatloaf mixture into a loaf and place into a greased loaf pan. In a small bowl, combine ketchup, brown sugar and mustard. Evenly spread ketchup brown sugar mixture over meatloaf. Bake for 1 hour and 15 minutes- 1 hour and 30 minutes.